Clinical Pathology Question Bank

Sample

1. Mediators such as histamine, thrombin, and platelet activating factor (PAF) stimulate the redistribution of which of the following from its normal intracellular stores in granules (Weibel-Palade bodies) to the cell surface?

Histamine, thrombin, and PAF cause rapid mobilization of P-selectin from Weibel-Palade bodies to the endothelial surface, mediating early leukocyte rolling.

Sample

2. Elephantiasis is associated with

Lymphatic filariasis with elephantiasis is caused by Wuchereria bancrofti.

Sample

3. Fungi within small cysts in the Virchow-Robin perivascular space is 380 characteristic of

Cryptococcus neoformans appears as yeast within small cystic spaces in the Virchow-Robin (perivascular) spaces ('soap bubble' lesions).

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4. Differential diagnosis of a child who presents with fever

Fever in a child can be due to malaria, dengue, poliovirus, and many other infections, so any of the above is a valid differential.

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5. A patient with hypochromic, microcytic anemia is deficient in

Hypochromic, microcytic anemia is due to iron deficiency (impaired hemoglobin synthesis).

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6. Cytokine activation of endothelium (with neutrophils) involves which of the following?

Cytokine activation of endothelium that recruits neutrophils is mediated principally by IL-1 and TNF (upregulating adhesion molecules).

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7. A child came in at the out-patient department because of generalized 438 edema accompanied by easily pluckable hair, listlessness, and loss of appetite. Most likely she is suffering from

Generalized edema with easily pluckable hair, listlessness, and anorexia in a child indicates kwashiorkor (protein malnutrition).

Sample

8. Grossly appears as a blind pouch on the antimesenteric side of the small bowel

A blind antimesenteric outpouching of the small bowel is a Meckel diverticulum (persistent vitelline duct).

Sample

9. Information to elicit in the clinical history of a patient with gastric carcinoma

A family history (relatives with gastric carcinoma) is the key hereditary risk factor to elicit. [REVIEW: keyed answer may be incorrect - diet (barbecued foods) and alcohol also contribute; selecting only family history (keyed c) is somewhat arbitrary, and 'any of the above' is defensible.]

Sample

10. Alcoholic patients may manifest

Alcoholics may develop Mallory-Weiss (longitudinal GE-junction) tears, esophageal squamous cell carcinoma, and acute gastritis - so any of the above can occur.