Pharmacy Question Bank

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1. Parkingsonism is probably due to

Parkinsonism results from a deficiency of dopamine in the basal ganglia (nigrostriatal pathway), producing the characteristic bradykinesia, rigidity, and tremor.

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2. A prominent toxic effect of local anaesthetics is

A prominent toxic effect of local anesthetics on the CNS is initial stimulation (restlessness, tremor, convulsions), which can be followed by CNS depression at higher concentrations.

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3. Which of the following could be used as an antidote for curare poisoning?

Neostigmine, an acetylcholinesterase inhibitor, antidotes curare (nondepolarizing blocker) poisoning by increasing acetylcholine at the neuromuscular junction to overcome the competitive blockade. Atropine is often co-given to limit muscarinic effects.

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4. Cigarette smoking increases the side effects of

Cigarette smoking increases the adverse effects (notably thromboembolic/cardiovascular risk) of oral contraceptives, especially in women over 35.

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5. Vivactil (protriptyline) is used mainly as a (an)

Protriptyline (Vivactil) is a tricyclic antidepressant used mainly to treat depression.

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6. Fluoxetine is a________ transport blocker

Fluoxetine is a selective serotonin reuptake inhibitor, blocking the serotonin transporter to increase synaptic serotonin.

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7. Which is the drug of choice for trigeminal neuralgia?

Carbamazepine is the drug of choice for trigeminal neuralgia, reducing the paroxysmal facial pain through sodium channel blockade.

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8. Which of the following may increase seizure activity in epileptic patients?

Amantadine (a dopaminergic/antiviral agent) can lower the seizure threshold and increase seizure activity in epileptic patients. The antiepileptic drugs listed would reduce seizures.

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9. Trazodone (Desyrel) is used primarily as a (an)

Trazodone (Desyrel) is used primarily as an antidepressant (and for insomnia due to its sedating effect).

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10. In addition to their marked potency, the loop diuretics Lasix and Edecrin have an added advantage of

Loop diuretics such as furosemide (Lasix) and ethacrynic acid (Edecrin) are effective when given orally (and intravenously), which is an advantage. They do cause electrolyte imbalance (hypokalemia), so the correct advantage is oral effectiveness.